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Table 2 Interacting enzymes predicted by Scansite.

From: Tyrosine phosphorylation of myosin heavy chain during skeletal muscle differentiation: an integrated bioinformatics approach

Sitea

Enzymeb

Gene Card

UniGenec

SAGEc

Full Name

163

EGFR Kinase

EGFR

Yes

No

EGFR (epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian))

 

Insulin Receptor Kinase

INSR

Yes

Yes

INSR (insulin receptor)

 

p85 SH2

PIK3R1

Yes

Yes

PIK3R1 (phosphoinositide-3-kinase, regulatory subunit, polypeptide 1 (p85 alpha))

 

Shc SH2

SHC1

No

No

SHC1 (SHC (Src homology 2 domain containing) transforming protein 1)

286

EGFR Kinase

EGFR

Yes

No

EGFR (epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian))

313

EGFR Kinase

EGFR

Yes

No

EGFR (epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian))

 

Fgr Kinase

FGR

No

No

FGR (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog)

 

PDGFR Kin

PDGFRB

No

Yes

PDGFRB (platelet-derived growth factor receptor, beta polypeptide)

 

Itk SH2

ITK

No

No

ITK (IL2-inducible T-cell kinase)

 

Fgr SH2

FGR

No

No

FGR (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog)

719

Lck Kinase

LCK

No

No

LCK (lymphocyte-specific protein tyrosine kinase)

 

Abl Kinase

ABL1

No

Yes

ABL1 (v-abl Abelson murine leukemia viral oncogene homolog 1)

 

Itk SH2

ITK

No

No

ITK (IL2-inducible T-cell kinase)

 

Src Kinase

SRC

Yes

No

SRC (v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian))

1492

Src Kinase

SRC

Yes

No

SRC (v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian))

 

Lck SH2

LCK

No

No

LCK (lymphocyte-specific protein tyrosine kinase)

 

Fgr SH2

FGR

No

No

FGR (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog)

 

Src SH2

SRC

Yes

No

SRC (v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian))

1856

Lck Kinase

LCK

No

No

LCK (lymphocyte-specific protein tyrosine kinase)

 

Src Kinase

SRC

Yes

No

SRC (v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian))

 

Abl Kinase

ABL1

No

Yes

ABL1 (v-abl Abelson murine leukemia viral oncogene homolog 1)

  1. a. Sites are numbered relative to the MHC sequence MYH1_HUMAN/P12882.
  2. b. Enzyme identified by Scansite.
  3. c Skeletal muscle expression data from GeneCards (Rebhan et al. 1997).
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Theoretical Biology and Medical Modelling

ISSN: 1742-4682