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Figure 1 | Theoretical Biology and Medical Modelling

Figure 1

From: Breakdown of accommodation in nerve: a possible role for persistent sodium current

Figure 1

Comparison of the new model with experimental data for: A) threshold electrotonus [40], B) recovery cycle [41], C) latent addition [10], and D) accommodation curve [5]. In threshold electrotonus, a sub-threshold conditioning pulse of 100 ms duration is used to alter the threshold of a test stimulus delayed with respect to the onset of the conditioning pulse. In the recovery cycle, the nerve fiber is excited by a supra-threshold stimulus and the threshold of a test stimulus is determined at inter-stimulus intervals (TISI) of 2 ms to 100 ms. In latent addition, a short duration sub-threshold conditioning stimulus is used to alter the threshold of a test stimulus; the onset of the test stimulus is delayed with regard to the onset of the conditioning stimulus. In the accommodation curve, the threshold of stimuli of the form IS(1-e-tτ) was determined, where τ was the time-constant of the current rise. In A, the bold line is the initial critical slope, which was estimated from the first four points in the accommodation curve where it is approximately a straight line. Experimental range: a) minimum and maximum of the experimental range, b) and c) mean ± standard deviation.

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