Table 1 Enzymes and rate equations of the prototype model

Glutathione turnover

GSHox

PPP

Chemical reaction

24

Glutathione reductase (NADPH)

GSSGR

PPP

Ordered Bi Ter mechanism

24

Glutathione reductase (NADH)

GSSGR2

PPP

Michaelis Menten mechanism

24

Glucose 6-phosphate dehydrogenase

G6PD

PPP

Ordered Bi Bi mechanism

17

6-Phosphogluconolactonase

6PGLase

PPP

Michaelis Menten mechanism

17

6-Phosphogluconate dehydrogenase

6PGLDH

PPP

Ordered Bi Ter mechanism

24

Ribose 5-phosphate isomerase

R5PI

PPP

Uni Uni mechanism

25

Xylulose 5-phosphate isomerase

X5PI

PPP

Uni Uni mechanism

25

Transketolase I

TK1

PPP

Ping-Pong Bi Bi mechanism

25

Transketolase II

TK2

PPP

Ping-Pong Bi Bi mechanism

25

Transaldolase

TA

PPP

Ping-Pong Bi Bi mechanism

25

Hexokinase

HK

Glycolysis

26

Phosphoglucoisomerase

PGI

Glycolysis

Uni Uni mechanism

25

Phosphofructokinase

PFK

Glycolysis

27

Aldolase

ALD

Glycolysis

Ordered Uni Bi mechanism

25

Triose phosphate isomerase

TPI

Glycolysis

Uni Uni mechanism

25

Glyceraldehyde phosphate dehydrogenase

GAPDH

Glycolysis

Chemical reaction

20

Phosphoglycerate kinase

PGK

Glycolysis

Chemical reaction

20

Diphosphoglycerate mutase

DPGM

Glycolysis

Michaelis Menten mechanism

20

Diphosphoglycerate phosphatase

DPGase

Glycolysis

Michaelis Menten mechanism

20

Phosphoglyceromutase

PGM

Glycolysis

Chemical reaction

20

Enolase

EN

Glycolysis

Chemical reaction

20

Pyruvate kinase

PK

Glycolysis

28

Pyruvate transport process

PYRtr

Transport

Michaelis Menten mechanism

22

Lactate dehydrogenase

LDH

Glycolysis

Chemical reaction

20

Lactate transport process

LACtr

Transport

Michaelis Menten mechanism

22

Leak of Potassium

K_Leak

Transport

9

Leak of Sodium

Na_Leak

Transport

9

Sodium/potassium pump

Pump

Transport

9

Adenosine transport process

ADEtr

Transport

Chemical reaction

13

AMP phosphohydrolase

AMPase

NM

Chemical reaction

20

Adenosine deaminase

ADA

NM

Michaelis Menten mechanism

20

Adenosine kinase

AK

NM

Michaelis Menten mechanism

20

Adenylate kinase

APK

NM

Chemical reaction

20

Adenosine triphosphate phosphohydrolase

ATPase

NM

Chemical reaction

8

Adenosine monophosphate deaminase

AMPDA

NM

Michaelis Menten mechanism

20

Inosine monophosphatase

IMPase

NM

Michaelis Menten mechanism

8

Purine nucleotide phosphorylase

PNPase

NM

Chemical reaction

23

Phosphoribosyl pyrophosphate synthetase

PRPPsyn

NM

8

Adenine phosphoribosyl transferase

ADPRT

NM

Michaelis Menten mechanism

8

Hypoxanthine-guanine phosphoryl transferase

HGPRT

NM

Michaelis Menten mechanism

8

Hypoxanthine transport process

HXtr

NM

29