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Table 2 Steady state of the RBC model.

From: Dynamic simulation of red blood cell metabolism and its application to the analysis of a pathological condition

  

Concentration (mM)

Metabolic intermediate

Abbreviation

Steady stateb

Literaturec

1,3-Diphosphoglycerate

13DPG

1.83E-04

4.00E-04

2-Phosphoglycerate

2PG

4.16E-03

1.40E-02 ± 5.00E-03

3-Phosphoglycerate

3PG

4.62E-02

4.50E-02

Adenosine

ADO

8.93E-06

1.20E-03 ± 3.00E-04

Dihydroxy acetone phosphate

DHAP

1.35E-01

1.40E-01 ± 8.00E-02

Erythrose 4-phosphate

E4P

1.17E+00

-

Fructose 6-phosphate

F6P

6.39E-02

1.60E-02 ± 3.00E-03

Fructose 1,6-diphosphate

FDP

1.14E-02

7.60E-03 ± 4.00E-03

Glucose 6-phosphate

G6P

1.96E-01

3.80E-02 ± 1.20E-02

Glyceraldehyde 3-phosphate

GA3P

6.24E-03

6.70E-03 ± 1.00E-03

Gluconolactone 6-phosphate

GL6P

7.62E-06

-

Gluconate 6-phosphate

GO6P

2.72E+00

-

Glutathione

GSH

3.21E+00

3.21E+00 ± 1.50E+00

Glutathione

GSSG

1.03E-04

-

Hypoxanthine

HXi

9.32E-06

2.00E-03

Inosine monophosphate

IMP

5.03E-03

1.00E-02

Inosine

INO

3.32E-08

1.00E-03

Potassium

Ki

1.26E+02

1.35E+02 ± 1.00E+01

Lactate

LACi

1.20E+00

1.10E+00 ± 5.00E-01

Nicotinamide adenine dinucleotide

NAD

8.87E-02d

-

Nicotinamide adenine dinucleotide

NADH

3.13E-04d

-

Nicotinamide adenine phosphate

NADP

8.06E-05d

-

Nicotinamide adenine phosphate

NADPH

6.58E-02d

6.58E-02

Sodium

Nai

2.27E+01

1.00E+01 ± 6.00E+00

Phosphoenolpyruvate

PEP

1.89E-02

1.70E-02 ± 2.00E-03

5-Phosphoribosyl 1-phosphate

PRPP

6.91E-05

5.00E-03 ± 1.00E-03

Pyruvate

PYRi

6.00E-02

7.70E-02 ± 5.00E-02

Inorganic phosphate

Pi

1.30E-01

1.00E+00

Ribose 1-phosphate

R1P

2.12E-05

6.00E-02

Ribose 5-phosphate

R5P

2.81E-04

-

Ribulose 5-phosphate

RU5P

1.48E-04

-

Sedoheptulose 7-phosphate

S7P

7.49E-02

-

Xylulose 5-phosphate

X5P

4.30E-04

-

2,3-Diphosphoglycerate

2,3-DPG

4.21E+00

4.50E+00 ± 5.00E-01

Adenosine diphosphate

ADP

2.20E-01

2.70E-01 ± 1.20E-01

Adenosine monophosphate

AMP

2.42E-02

8.00E-02 ± 9.00E-03

Adenosine triphosphate

ATP

1.57E+00

1.54E-00 ± 2.50E-01

  1. The values are given in scientific notation; E-01 denotes multiplication by 10-1.
  2. aThe initial data set was from experimental data in the literature and from predictions of previous simulation models [12].
  3. bThe simulation was run for more than 1,000,000 seconds in simulation time until the model reached steady state.
  4. c Biochemical experimental data taken from the literature and reported in Joshi and Palsson [11].
  5. d NAD(H) and NADP(H) pools are kept constant.