Figure 1
From: Volume of the effect compartment in simulations of neuromuscular block
Upper panel: The amounts of muscle relaxant D (KD = 1·10-7 M) in plasma and compartment1 and the free amounts in the effect compartment assigned a small (Ve = 4.4·10-5 L·kg-1) or a large (Ve = 9.23·10-2 L·kg-1) volume. All the amounts are normalized to the injected dose (= ED50 = 2.23·10-7 mol·kg-1). Solid and dashed lines indicate the amounts contained in the small and the large effect compartment, respectively. Filled circles denote the target amounts in plasma defined by the triexponential function. The three curves for the amounts in plasma overlap. The estimates were obtained at 0.1 min intervals. Lower panel: Time course of the neuromuscular block (NMB) by ED50 of the muscle relaxant D. NMB was calculated using Eq 1 (Appendix), [D]e for the small and large volume of the effect compartment presented in the upper panel, and by setting γ = 4.0 and IC50 = 7·10-7 M. The lines are identical to those in the upper panel for the small and large volume of the effect compartment.