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Figure 2 | Theoretical Biology and Medical Modelling

Figure 2

From: Volume of the effect compartment in simulations of neuromuscular block

Figure 2

Upper panel: Neuromuscular block (NMB) calculated as a function of the peak concentrations of muscle relaxant D in the effect compartment using Eq 1 presented in the Appendix (γ = 4.0 and IC50 = 7·10-7 M). The doses presented along the abscissa refer to the doses that established the peak concentrations. The range of NMB is from NMB05 to NMB95. One thousand logarithmically equidistant values were used for a 10-fold increase in doses. The volumes of the effect compartment and the lines are identical to those presented in Figure 1. Lower panel: Onset times as a function of the magnitude of NMB. Onset times are defined as the times after the bolus intravenous injection of muscle relaxant D needed to establish peak NMB, from NMB05 to NMB95. Other details are identical to those in the upper panel.

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