Skip to main content
Figure 3 | Theoretical Biology and Medical Modelling

Figure 3

From: Volume of the effect compartment in simulations of neuromuscular block

Figure 3

Upper panel: Values estimated for the transport rate constant between the effect and the central compartment, ke1, as a function of the volume assigned to the effect compartment, Ve. The dose of the muscle relaxant D = ED50 = 2.23·10-7 mol·kg-1 and KD = 1·10-7 M. Lower panel: Amounts of the muscle relaxant D (left Y-axis) bound to the receptors (filled upright triangles) and the amounts free (filled diamonds). The amounts are normalized to the injected dose presented in the upper panel. The ratio of the bound to the total amounts (empty circles; total = bound + free; right Y-axis) in the effect compartment is presented as a function of the volume assigned to the effect compartment.

Back to article page