Figure 4
From: Volume of the effect compartment in simulations of neuromuscular block
Upper panel: The peak free concentrations of muscle relaxant D in the effect compartment calculated with variable doses of D as a function of the volumes assigned to the effect compartment. The assigned volumes were: 1·10-6, 3.16·10-6, 1·10-5, 3.16·10-5, 1·10-4, 3.16·10-4, 1·10-3, 3.16·10-3, 1·10-2, 3.16·10-2, and 1·10-1 L·kg-1. The bold solid and the dotted lines indicate the lowest and the highest assigned volumes, respectively. Concentrations for the intermediate volumes are indicated in sequence by thin solid lines. The three dashed lines parallel with the X-axis represent the free concentration of D for NMB95 (IC95, upper line), for NMB50 (IC50, middle line) and for NMB05 (IC05, lower line). The concentrations for IC05 and IC95 were calculated based on γ = 4.0 (Eq 1, Appendix). Lower panel: Times to NMB05 (open circles) and NMB95 (filled circles, left Y-axis) as a function of the volumes assigned to the effect compartment, Ve. Neuromuscular block was calculated using Eq 1 (IC50 = 7·10-7 M, γ = 4) and the peak free concentrations of D presented in the upper panel. The values of the exponent γf (filled diamonds, right Y-axis) were obtained by fitting Eq 2 to the calculated NMB.