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Table 3 Comparisons of the dynamic model and the hybrid model of the erythrocyte pathway shown in Fig. 5. The maximum errors were measured within one numerical integration step. "Perturbation" denotes whether the errors were measured under a steady-state condition (-) or after a three-fold increase of FDP concentration (+).

From: Hybrid dynamic/static method for large-scale simulation of metabolism

 

Perturbation

Maximum error (concentration)

Maximum error (reaction rate)

Boundary

-

7.796 × 10-3 (GL6P)

1.555 × 10-7 (R5PI)

 

+

1.153 × 10-7 (GL6P)

3.020 × 10-5 (TK1)

Static part

-

1.111 × 10-8 (GSSG)

2.170 × 10-4 (6PGODH)

 

+

4.282 × 10-12 (GO6P)

2.170 × 10-4 (6PGODH)