Figure 1From: Modeling the signaling endosome hypothesis: Why a drive to the nucleus is better than a (random) walkSimplified diagram showing the activation of STAT-3 and Erk1/2 downstream from EGF binding to EGFR. In the general model of signal transduction, the cascading chain of phosphorylation events culminating in activation of transcription factors such as STAT-3 and Erk1/2 depends upon the diffusion of these molecules from the site of signal initiation at the plasma membrane to the site of transcriptional regulation within the nucleus.Back to article page