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Figure 1 | Theoretical Biology and Medical Modelling

Figure 1

From: Modeling the signaling endosome hypothesis: Why a drive to the nucleus is better than a (random) walk

Figure 1

Simplified diagram showing the activation of STAT-3 and Erk1/2 downstream from EGF binding to EGFR. In the general model of signal transduction, the cascading chain of phosphorylation events culminating in activation of transcription factors such as STAT-3 and Erk1/2 depends upon the diffusion of these molecules from the site of signal initiation at the plasma membrane to the site of transcriptional regulation within the nucleus.

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