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Figure 4 | Theoretical Biology and Medical Modelling

Figure 4

From: Modeling the signaling endosome hypothesis: Why a drive to the nucleus is better than a (random) walk

Figure 4

Growth factor receptors are internalized into clathrin-coated vesicles (CCVs) following ligand binding and receptor activation (1–5). These CCVs are uncoated (6) and mature into early endosomes (EE) (7) that may serve as transport endosomes [48]. The concentration of growth factor in transport endosomes is high enough to guarantee effectively 100% receptor occupancy. Hence, if the endosome-associated receptor encounters a phosphatase, the phosphorylation signal is rapidly regenerated.

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