TY - JOUR AU - Mann, D. L. AU - Deswal, A. PY - 2003 DA - 2003// TI - Angiotensin-receptor blockade in acute myocardial infarction – a matter of dose JO - N Engl J Med. VL - 349 UR - https://doi.org/10.1056/NEJMe038163 DO - 10.1056/NEJMe038163 ID - Mann2003 ER - TY - STD TI - United States Food and Drug Administration: Approval Package for NDA21-286. Pharmacology Review, figures 1.1.1.1,1.1.1.3 and1.1.1.4, http://www.fda.gov/cder/foi/nda/2002/21-286_Benicar_pharmr_P1.pdf UR - http://www.fda.gov/cder/foi/nda/2002/21-286_Benicar_pharmr_P1.pdf ID - ref2 ER - TY - JOUR AU - Izuhara, Y. AU - Nangaku, M. AU - Inagi, R. AU - Tominaga, N. AU - Aizawa, T. AU - Kurokawa, K. AU - van Ypersele de Strihou, C. AU - Miyata, T. PY - 2005 DA - 2005// TI - Renoprotective Properties of Angiotensin Receptor Blockers beyond Blood Pressure Lowering JO - J Am Soc Nephrol VL - 16 UR - https://doi.org/10.1681/ASN.2005050522 DO - 10.1681/ASN.2005050522 ID - Izuhara2005 ER - TY - JOUR AU - Lewis, E. J. AU - Lewis, J. B. PY - 2003 DA - 2003// TI - Treatment of diabetic nephropathy with angiotensin II receptor antagonist JO - Clin Exp Nephrol VL - 7 UR - https://doi.org/10.1007/s101570300000 DO - 10.1007/s101570300000 ID - Lewis2003 ER - TY - JOUR AU - Brenner, B. M. AU - Cooper, M. E. AU - de Zeeuw, D. AU - Keane, W. F. AU - Mitch, W. E. AU - Parving, H. H. PY - 2001 DA - 2001// TI - Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy JO - N Engl J Med VL - 345 UR - https://doi.org/10.1056/NEJMoa011161 DO - 10.1056/NEJMoa011161 ID - Brenner2001 ER - TY - JOUR AU - Viberti, G. C. AU - Wheeldon, M. N. PY - 2002 DA - 2002// TI - Microalbuminuria reduction with valsartan in patients with type 2 diabetes mellitus: A blood pressure-independent effect JO - Circulation VL - 106 UR - https://doi.org/10.1161/01.CIR.0000024416.33113.0A DO - 10.1161/01.CIR.0000024416.33113.0A ID - Viberti2002 ER - TY - JOUR AU - Schieffer, B. AU - Bunte, C. AU - Witte, J. AU - Hoeper, K. AU - Boger, R. H. AU - Schwedhelm, E. AU - Drexler, H. PY - 2004 DA - 2004// TI - Comparative effects of AT1-antagonism and angiotensin-converting enzyme inhibition on markers of inflammation and platelet aggregation in patients with coronary artery disease JO - J Am Coll Cardiol VL - 44 UR - https://doi.org/10.1016/j.jacc.2004.03.065 DO - 10.1016/j.jacc.2004.03.065 ID - Schieffer2004 ER - TY - JOUR AU - Luno, J. AU - Praga, M. AU - de Vinuesa, S. G. PY - 2005 DA - 2005// TI - The reno-protective effect of the dual blockade of the renin angiotensin system (RAS) JO - Curr Pharm Des VL - 11 UR - https://doi.org/10.2174/1381612053507413 DO - 10.2174/1381612053507413 ID - Luno2005 ER - TY - CHAP AU - Waterhouse, J. C. AU - Marshall, T. G. AU - Fenter, B. AU - Mangin, M. AU - Blaney, G. ED - Stoltz, V. D. PY - 2006 DA - 2006// TI - High levels of active 1,25-dihydroxyvitamin D despite low levels of the 25-hydroxyvitamin D precursor - Implications of dysregulated vitamin D for disgnosis and treatment of Chronic Disease BT - Vitamin D: New Research PB - Nova Science Publishers CY - New York ID - Waterhouse2006 ER - TY - JOUR AU - Marshall, T. G. AU - Marshall, F. E. PY - 2004 DA - 2004// TI - Sarcoidosis succumbs to antibiotics – implications for autoimmune disease JO - Autoimmun Rev VL - 3 UR - https://doi.org/10.1016/j.autrev.2003.10.001 DO - 10.1016/j.autrev.2003.10.001 ID - Marshall2004 ER - TY - JOUR AU - Raz, E. AU - Tighe, H. AU - Sato, Y. AU - Corr, M. AU - Dudler, J. A. AU - Roman, M. AU - Swain, S. L. AU - Spiegelberg, H. L. AU - Carson, D. A. PY - 1996 DA - 1996// TI - Preferential induction of a Th1 immune response and inhibition of specific IgE antibody formation by plasmid DNA immunization JO - Proc Natl Acad Sci USA VL - 93 UR - https://doi.org/10.1073/pnas.93.10.5141 DO - 10.1073/pnas.93.10.5141 ID - Raz1996 ER - TY - JOUR AU - Cantorna, M. T. AU - Zhu, Y. AU - Froicu, M. AU - Wittke, A. PY - 2004 DA - 2004// TI - Vitamin D status, 1,25-dihydroxyvitamin D3, and the immune system JO - Am J Clin Nutr VL - 80 ID - Cantorna2004 ER - TY - JOUR AU - Mallat, Z. AU - Ait-Oufella, H. AU - Tedgui, A. PY - 2005 DA - 2005// TI - Regulatory T cell responses: potential role in the control of atherosclerosis JO - Curr Opin Lipidol VL - 16 UR - https://doi.org/10.1097/01.mol.0000182532.11512.90 DO - 10.1097/01.mol.0000182532.11512.90 ID - Mallat2005 ER - TY - JOUR AU - Yoon, J. W. AU - Jun, H. S. PY - 2005 DA - 2005// TI - Autoimmune destruction of pancreatic Beta cells JO - Am J Ther VL - 12 UR - https://doi.org/10.1097/01.mjt.0000178767.67857.63 DO - 10.1097/01.mjt.0000178767.67857.63 ID - Yoon2005 ER - TY - JOUR AU - Wittke, A. AU - Weaver, V. AU - Mahon, B. D. AU - August, A. AU - Cantorna, M. T. PY - 2004 DA - 2004// TI - Vitamin D receptor-deficient mice fail to develop experimental allergic asthma JO - J Immunol. VL - 173 UR - https://doi.org/10.4049/jimmunol.173.5.3432 DO - 10.4049/jimmunol.173.5.3432 ID - Wittke2004 ER - TY - JOUR AU - Dusso, A. S. AU - Kamimura, S. AU - Gallieni, M. AU - Zhong, M. AU - Negrea, L. AU - Shapiro, S. AU - Slatopolsky, E. PY - 1997 DA - 1997// TI - gamma-Interferon-induced resistance to 1,25-(OH)2 D3 in human monocytes and macrophages: a mechanism for the hypercalcemia of various granulomatoses JO - J Clin Endocrinol Metab VL - 82 ID - Dusso1997 ER - TY - JOUR AU - Potashnik, G. AU - Lunenfeld, E. AU - Levitas, E. AU - Itskovitz, J. AU - Albutiano, S. AU - Yankowitz, N. AU - Sonin, Y. AU - Levy, J. AU - Glezerman, M. AU - Shany, S. PY - 1992 DA - 1992// TI - The relationship between endogenous oestradiol and vitamin D3 metabolites in serum and follicular fluid during ovarian stimulation for in-vitro fertilization and embryo transfer JO - Hum Reprod VL - 7 ID - Potashnik1992 ER - TY - JOUR AU - Chatterjee, M. PY - 2001 DA - 2001// TI - Vitamin D and genomic stability JO - Mutat Res. VL - 475 UR - https://doi.org/10.1016/S0027-5107(01)00080-X DO - 10.1016/S0027-5107(01)00080-X ID - Chatterjee2001 ER - TY - JOUR AU - Nagpal, S. AU - Na, S. AU - Rathnachalam, R. PY - 2005 DA - 2005// TI - Noncalcemic actions of vitamin D receptor ligands JO - Endocr Rev VL - 26 UR - https://doi.org/10.1210/er.2004-0002 DO - 10.1210/er.2004-0002 ID - Nagpal2005 ER - TY - JOUR AU - Benson, S. C. AU - Pershadsingh, H. A. AU - Ho, C. I. AU - Chittiboyina, A. AU - Desai, P. AU - Pravenec, M. AU - Qi, N. AU - Wang, J. AU - Avery, M. A. AU - Kurtz, T. W. PY - 2004 DA - 2004// TI - Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma-modulating activity JO - Hypertension VL - 43 UR - https://doi.org/10.1161/01.HYP.0000123072.34629.57 DO - 10.1161/01.HYP.0000123072.34629.57 ID - Benson2004 ER - TY - JOUR AU - Cabrero, A. AU - Laguna, J. C. AU - Vazquez, M. PY - 2002 DA - 2002// TI - Peroxisome proliferator-activated receptors and the control of inflammation JO - Curr Drug Targets Inflamm Allergy VL - 1 UR - https://doi.org/10.2174/1568010023344616 DO - 10.2174/1568010023344616 ID - Cabrero2002 ER - TY - JOUR AU - Genolet, R. AU - Wahli, W. AU - Michalik, L. PY - 2004 DA - 2004// TI - PPARs as drug targets to modulate inflammatory responses? JO - Curr Drug Targets Inflamm Allergy VL - 3 UR - https://doi.org/10.2174/1568010042634578 DO - 10.2174/1568010042634578 ID - Genolet2004 ER - TY - JOUR AU - Preobrazhensky, A. A. AU - Dragan, S. AU - Kawano, T. AU - Gavrilin, M. A. AU - Gulina, I. V. AU - Chakravarty, L. AU - Kolattukudy, P. E. PY - 2000 DA - 2000// TI - Monocyte chemotactic protein-1 receptor CCR2B is a glycoprotein that has tyrosine sulfation in a conserved extracellular N-terminal region JO - J Immunol. VL - 165 UR - https://doi.org/10.4049/jimmunol.165.9.5295 DO - 10.4049/jimmunol.165.9.5295 ID - Preobrazhensky2000 ER - TY - JOUR AU - Tanaka, S. AU - Green, S. R. AU - Quehenberger, O. PY - 2002 DA - 2002// TI - Differential expression of the isoforms for the monocyte chemoattractant protein-1 receptor, CCR2, in monocytes JO - Biochem Biophys Res Commun. VL - 290 UR - https://doi.org/10.1006/bbrc.2001.6149 DO - 10.1006/bbrc.2001.6149 ID - Tanaka2002 ER - TY - JOUR AU - Casey, P. J. AU - Gilman, A. G. PY - 1988 DA - 1988// TI - G protein involvement in receptor-effector coupling JO - J Biol Chem. VL - 263 ID - Casey1988 ER - TY - STD TI - AutoDock, Automatic Docking of Flexible Ligands to Macromolecules.http://www.scripps.edu/mb/olson/doc/autodock/ UR - http://www.scripps.edu/mb/olson/doc/autodock/ ID - ref26 ER - TY - STD TI - Morris GM, Goodsell DS, Halliday RS, Huey R, Hart WE, Belew RK, Olson AJ: Automated docking using Lamarckian genetic algorithm and an empirical binding free energy function. J Comp Chem. 19: 1639-1662. 10.1002/(SICI)1096-987X(19981115)19:14<1639::AID-JCC10>3.0.CO;2-B. ID - ref27 ER - TY - JOUR AU - Osterberg, F. AU - Morris, G. M. AU - Sanner, M. F. AU - Olson, A. J. AU - Goodsell, D. S. PY - 2002 DA - 2002// TI - Automated docking to multiple target structures: incorporation of protein mobility and structural water heterogeneity in AutoDock JO - Proteins. VL - 46 UR - https://doi.org/10.1002/prot.10028 DO - 10.1002/prot.10028 ID - Osterberg2002 ER - TY - JOUR AU - Toprakci, M. AU - Yelekci, K. PY - 2005 DA - 2005// TI - Docking studies on monoamine oxidase-B inhibitors: estimation of inhibition constants (K(i)) of a series of experimentally tested compounds JO - Bioorg Med Chem Lett. VL - 15 UR - https://doi.org/10.1016/j.bmcl.2005.07.043 DO - 10.1016/j.bmcl.2005.07.043 ID - Toprakci2005 ER - TY - JOUR AU - Chen, K. AU - Adelstein, S. J. AU - Kassis, A. I. PY - 2004 DA - 2004// TI - Molecular simulation of ligand-binding with DNA: implications for 125I-labeled pharmaceutical design JO - Int J Radiat Biol VL - 80 UR - https://doi.org/10.1080/09553000400017630 DO - 10.1080/09553000400017630 ID - Chen2004 ER - TY - JOUR AU - Xu, H. E. AU - Lambert, M. H. AU - Montana, V. G. AU - Plunket, K. D. AU - Moore, L. B. AU - Collins, J. L. AU - Oplinger, J. A. AU - Kliewer, S. A. AU - Gampe, R. T. AU - McKee, D. D. AU - Moore, J. T. AU - Willson, T. M. PY - 2001 DA - 2001// TI - Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors JO - Proc Natl Acad Sci U S A VL - 98 UR - https://doi.org/10.1073/pnas.241410198 DO - 10.1073/pnas.241410198 ID - Xu2001 ER - TY - JOUR AU - Rochel, N. AU - Wurtz, J. M. AU - Mitschler, A. AU - Klaholz, B. AU - Moras, D. PY - 2000 DA - 2000// TI - The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand JO - Mol Cell VL - 5 UR - https://doi.org/10.1016/S1097-2765(00)80413-X DO - 10.1016/S1097-2765(00)80413-X ID - Rochel2000 ER - TY - JOUR AU - Eelen, G. AU - Verlinden, L. AU - Rochel, N. AU - Claessens, F. AU - De Clercq, P. AU - Vandewalle, M. AU - Tocchini-Valentini, G. AU - Moras, D. AU - Bouillon, R. AU - Verstuyf, A. PY - 2005 DA - 2005// TI - Superagonistic action of 14-epi-analogs of 1,25-dihydroxyvitamin D explained by vitamin D receptor-coactivator interaction JO - Mol Pharmacol VL - 67 UR - https://doi.org/10.1124/mol.104.008730 DO - 10.1124/mol.104.008730 ID - Eelen2005 ER - TY - STD TI - Scripps Research Institute, Molecular Graphics Laboratory, MGLtools. http://www.scripps.edu/~sanner/software/ UR - http://www.scripps.edu/~sanner/software/ ID - ref34 ER - TY - STD TI - The Python Molecular Viewer. http://www.pymol.org UR - http://www.pymol.org ID - ref35 ER - TY - JOUR AU - Strader, C. D. AU - Fong, T. M. AU - Graziano, M. P. AU - Tota, M. R. PY - 1995 DA - 1995// TI - The family of G-protein-coupled receptors JO - FASEB J VL - 9 ID - Strader1995 ER - TY - JOUR AU - Shi, X. F. AU - Liu, S. AU - Xiangyu, J. AU - Zhang, Y. AU - Huang, J. AU - Liu, S. AU - Liu, C. Q. PY - 2002 DA - 2002// TI - Structural analysis of human CCR2b and primate CCR2b by molecular modeling and molecular dynamics simulation JO - J Mol Model (Online) VL - 8 UR - https://doi.org/10.1007/s00894-002-0089-6 DO - 10.1007/s00894-002-0089-6 ID - Shi2002 ER - TY - JOUR AU - Pappu, R. V. AU - Marshall, G. R. AU - Ponder, J. W. PY - 1999 DA - 1999// TI - A potential smoothing algorithm accurately predicts transmembrane helix packing JO - Nat Struct Biol VL - 6 UR - https://doi.org/10.1038/4922 DO - 10.1038/4922 ID - Pappu1999 ER - TY - STD TI - TINKER – Software tools for molecular design. http://dasher.wustl.edu/tinker UR - http://dasher.wustl.edu/tinker ID - ref39 ER - TY - JOUR AU - Sali, A. AU - Blundell, T. L. PY - 1993 DA - 1993// TI - Comparative protein modelling by satisfaction of spatial restraints JO - J Mol Biol. VL - 234 UR - https://doi.org/10.1006/jmbi.1993.1626 DO - 10.1006/jmbi.1993.1626 ID - Sali1993 ER - TY - STD TI - MODELLER Program for comparative protein structure modelling by satisfaction of spatial restraints. http://salilab.org/modeller/modeller.html UR - http://salilab.org/modeller/modeller.html ID - ref41 ER - TY - JOUR AU - Baba, M. AU - Nishimura, O. AU - Kanzaki, N. AU - Okamoto, M. AU - Sawada, H. AU - Iizawa, Y. AU - Shiraishi, M. AU - Aramaki, Y. AU - Okonogi, K. AU - Ogawa, Y. AU - Meguro, K. AU - Fujino, M. PY - 1999 DA - 1999// TI - A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity JO - Proc Natl Acad Sci USA VL - 96 UR - https://doi.org/10.1073/pnas.96.10.5698 DO - 10.1073/pnas.96.10.5698 ID - Baba1999 ER - TY - JOUR AU - Martin, S. S. AU - Boucard, A. A. AU - Clement, M. AU - Escher, E. AU - Leduc, R. AU - Guillemette, G. PY - 2004 DA - 2004// TI - Analysis of the third transmembrane domain of the human type 1 angiotensin II receptor by cysteine scanning mutagenesis JO - J Biol Chem. VL - 279 UR - https://doi.org/10.1074/jbc.M407965200 DO - 10.1074/jbc.M407965200 ID - Martin2004 ER - TY - JOUR AU - Goodsell, D. S. AU - Olson, A. J. PY - 1990 DA - 1990// TI - Automated Docking of Substrates to Proteins by Simulated Annealing JO - Proteins VL - 8 UR - https://doi.org/10.1002/prot.340080302 DO - 10.1002/prot.340080302 ID - Goodsell1990 ER - TY - JOUR AU - Morris, G. M. AU - Goodsell, D. S. AU - Huey, R. AU - Olson, A. J. PY - 1996 DA - 1996// TI - Distributed Automated Docking of Flexible Ligands to Proteins: Parallel Applications of AutoDock 2.4 JO - J Comput Aided Mol Des VL - 10 UR - https://doi.org/10.1007/BF00124499 DO - 10.1007/BF00124499 ID - Morris1996 ER - TY - JOUR AU - Omdahl, J. L. AU - Morris, H. A. AU - May, B. K. PY - 2002 DA - 2002// TI - Hydroxylase enzymes of the vitamin D pathway: expression, function, and regulation JO - Annu Rev Nutr VL - 22 UR - https://doi.org/10.1146/annurev.nutr.22.120501.150216 DO - 10.1146/annurev.nutr.22.120501.150216 ID - Omdahl2002 ER - TY - JOUR AU - Wang, J. AU - Cieplak, P. AU - Kollman, P. A. PY - 2000 DA - 2000// TI - How Well Does a Restrained Electrostatic Potential (RESP) Model Perform in Calcluating Conformational Energies of Organic and Biological Molecules? JO - J Comput Chem VL - 21 UR - https://doi.org/3.0.CO;2-F DO - 3.0.CO;2-F ID - Wang2000 ER - TY - STD TI - Akira Dobashi's: 3D Pharmaceutical Structure Database. Tokyo University of Pharmacy and Life Sciences, http://www.pharmis.org/3dpsd/index.htm UR - http://www.pharmis.org/3dpsd/index.htm ID - ref48 ER - TY - STD TI - Ghemical molecular modelling package. http://www.bioinformatics.org/ghemical/ UR - http://www.bioinformatics.org/ghemical/ ID - ref49 ER - TY - BOOK AU - Blair, J. D. PY - 1998 DA - 1998// TI - SAMBA: Integrating UNIX and Windows PB - SSC Publishing CY - Seattle ID - Blair1998 ER - TY - JOUR AU - Acevedo, A. AU - Stoynova, L. AU - Davis, K. AU - Solorzano, R. AU - Collins, E. D. PY - 2004 DA - 2004// TI - Role of residues 143 and 278 of the human nuclear Vitamin D receptor in the full-length and Delta165-215 deletion mutant JO - J Steroid Biochem Mol Biol VL - 89–90 UR - https://doi.org/10.1016/j.jsbmb.2004.03.051 DO - 10.1016/j.jsbmb.2004.03.051 ID - Acevedo2004 ER - TY - STD TI - Tsukahara T, Tsukahara R, Yasuda S, Makarova N, Valentine WJ, Allison P, Yuan H, Baker DL, Li Z, Bittman R, Parrill A, Tigyi G: Different residues mediate recognition of 1-O-oleyl-lysophosphatidic acid and rosiglitazone in the ligand binding domain of PPAR1. J Biol Chem. 2005 Dec 1. ID - ref52 ER - TY - JOUR AU - Wallace, A. C. AU - Laskowski, R. A. AU - Thornton, J. M. PY - 1995 DA - 1995// TI - A program to generate schematic diagrams of protein-ligand interactions JO - Protein Eng VL - 8 UR - https://doi.org/10.1093/protein/8.2.127 DO - 10.1093/protein/8.2.127 ID - Wallace1995 ER - TY - STD TI - LIGPLOT-Program for automatically plotting protein-ligand interactions. http://www.biochem.ucl.ac.uk/bsm/ligplot/ligplot.html UR - http://www.biochem.ucl.ac.uk/bsm/ligplot/ligplot.html ID - ref54 ER - TY - JOUR AU - McDonald, I. K. AU - Thornton, J. M. PY - 1994 DA - 1994// TI - Satisfying Hydrogen Bonding Potential in Proteins JO - J Mol Biol. VL - 238 UR - https://doi.org/10.1006/jmbi.1994.1334 DO - 10.1006/jmbi.1994.1334 ID - McDonald1994 ER - TY - STD TI - HBPLUS-Hydrogen Bond Calculation Program. http://www.biochem.ucl.ac.uk/bsm/hbplus/home.html UR - http://www.biochem.ucl.ac.uk/bsm/hbplus/home.html ID - ref56 ER - TY - JOUR AU - Shaffer, P. L. AU - McDonnell, D. P. AU - Gewirth, D. T. PY - 2005 DA - 2005// TI - Characterization of transcriptional activation and DNA-binding functions in the hinge region of the vitamin D receptor JO - Biochemistry. VL - 44 UR - https://doi.org/10.1021/bi0477182 DO - 10.1021/bi0477182 ID - Shaffer2005 ER -