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Table 1 Estimated Inhibition Constant, Ki (nmol), for ARBs docking into several immune system receptors.

From: Common angiotensin receptor blockers may directly modulate the immune system via VDR, PPAR and CCR2b

  Olmesartan Telmisartan Valsartan Irbesartan Candesartan Losartan
VDR,1DB1 12, 27 0.038 14 10 35 77
VDR,1TXI 10,34 0.039 14 12 30 74
PPAR 12 0.29 12 6 61 3
CCR2b * 9* 25* 22* 9* 39* 25*
AT2R1 * 0.10* 0.10* 0.3* 0.17* 1.5* 0.50*
  1. *Note 1: CCR2b and AT2R1 are theoretical models, and may not be reliable (see text)
  2. Note 2: (conventional ligand binding data): 1,25-dihydroxyvitamin-D docks into VDR (PDB:1DB1) with Ki = 0.029 nmol and into VDR (PDB:1TXI) with Ki= 0.059 nmol
  3. TX522 docks into VDR (PDB:1DB1) with Ki = 0.071 nmol and VDR (PDB:1TXI) with Ki = 0.12 nmol
  4. TAK779 docks into putative CCR2b with Ki = 10 nmol
  5. GI262570 docks into PPAR (PDB:1FM9) with Ki = 0.040 nmol.