Theoretical Biology and Medical Modelling

Table 2 Regions of the state space reached by the continuous version of the Th model, as revealed by a large number of simulations starting from a random initial state. ^a

From: A method for the generation of standardized qualitative dynamical systems of regulatory networks

	Th0		Th1		Th2
	Avrg.	Std. Dev.	Avrg.	Std. Dev.	Avrg.	Std. Dev.
GATA3	0.00003	0.00008	0.00000	0.00000	0.99997	0.00007
IFN-β	0.00000	0.00000	0.00000	0.00000	0.00000	0.00000
IFN-βR	0.00000	0.00001	0.00000	0.00001	0.00000	0.00001
IFN-γ	0.00005	0.00013	0.71438	0.00059	0.00000	0.00001
IFN-γR	0.00004	0.00011	0.97169	0.00040	0.00001	0.00004
IL-10	0.00003	0.00007	0.00000	0.00001	0.99999	0.00004
IL-10R	0.00005	0.00010	0.00000	0.00001	0.99999	0.00002
IL-12	0.00000	0.00001	0.00000	0.00000	0.00000	0.00001
IL-12R	0.00000	0.00002	0.00000	0.00001	0.00000	0.00001
IL-18	0.00000	0.00001	0.00000	0.00000	0.00000	0.00001
IL-18R	0.00000	0.00002	0.00000	0.00001	0.00000	0.00001
IL-4	0.00002	0.00006	0.00000	0.00001	0.99995	0.00011
IL-4R	0.00002	0.00004	0.00000	0.00001	0.99990	0.00022
IRAK	0.00001	0.00005	0.00000	0.00003	0.00001	0.00004
JAK1	0.00002	0.00008	0.00487	0.00005	0.00001	0.00005
NFAT	0.00001	0.00003	0.00000	0.00002	0.00001	0.00003
SOCS1	0.00009	0.00022	0.89486	0.00037	0.00002	0.00006
STAT1	0.00001	0.00005	0.00051	0.00003	0.00002	0.00005
STAT3	0.00012	0.00023	0.00001	0.00002	1.00000	0.00002
STAT4	0.00001	0.00003	0.00000	0.00003	0.00000	0.00001
STAT6	0.00001	0.00004	0.00000	0.00002	0.99990	0.00023
T-bet	0.00007	0.00018	0.89485	0.00036	0.00000	0.00000
TCR	0.00000	0.00001	0.00000	0.00000	0.00000	0.00001

a. Only three regions of the activation space were found in the continuous Th model after running it from 50,000 different random initial states. The average and standard deviations of all the results are shown. All variables had a random initial state in the closed interval [0,1]. From the 50,000 simulations, 8195 (16.39%) converged to the Th0 state, 25575 (51.15%) to the Th1 state, and 16230 (32.46%) to the Th2 state. Bold numbers as in Table 1.

Back to article page

ISSN: 1742-4682

Contact us

Submission enquiries: Access here and click Contact Us
General enquiries: info@biomedcentral.com