The predicted lipid-binding site of the alpha-Actinin dimer. The coordinates of the alpha-actinin rod domain (PDB 1HCI) are displayed with one monomer of the dimer shown in silver and the other in gold. The predicted lipid-binding sites are colored yellow. Amino and carboxyl termini are indicated in blue and red, respectively. (a) Ribbon model, (b) Space-filling representation, and (c) Electrostatic field potentials (orientation of the protein is identical to that viewed in (a) and (b)). The colors red, white and blue are used to indicate negative, neutral and positive field potentials (c), respectively.