Protein-lipid interactions: correlation of a predictive algorithm for lipid-binding sites with three-dimensional structural data

Table 1 Characteristics of the three-dimensional structures. Coordinate files were obtained from the Protein Data Bank [20]; 1HCI [28]; 1K8K [49]; 1IZN [61]; 1MIX [83]; 1MIZ [83]; 1QKR [93]; 1TR2 [92]; 1ST6 [94].

#	Protein	Crystal	Organism	Sequence Included	Resolution (Å)	Refinement (R-value)	PDB ID
1	α-actinin	Rod domain: spectrin-like repeats 1–4	Homo sapiens	274–746	2.8	0.270	1HCI
2	Arp2	Arp2/3 complex	Bos taurus	154–343¹	2.0	0.216	1K8K
3	CapZβ-1	CapZ	Gallus gallus	2–271	2.1	0.222	1IZN
4	Talin	FERM domain (subdomains 2 and 3)	Gallus gallus	196–400	1.75	0.199	1MIX
		FERM domain/Integrin β3 tail fragment (739–743) Complex	Gallus gallus	200–400	1.9	0.204	1MIZ
5	Vinculin	Tail Domain	Gallus gallus	881–1061²	1.8	0.200	1QKR
		Full length (Selenium-methionine derivative)	Homo sapiens	1–1066	2.85	0.251	1TR2
		Full length	Gallus gallus	1–1065	3.1	0.316	1ST6

• ¹Subdomains 1 and 2 are partially disordered and not included in the refined model.
• ²Residues 856–874 could not be adequately modeled or refined and are not included in the PDB coordinates.

ISSN: 1742-4682