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Figure 3 | Theoretical Biology and Medical Modelling

Figure 3

From: Parameter estimation in biochemical systems models with alternating regression

Figure 3

Summary of convergence patterns of AR. Panel A: all variables are initially used as regressors and constraints are imposed afterwards; Panel B: regression with the "union" of variables of both terms; Panel C: only those variables that are known to appear in the production or degradation term, respectively, are used as regressors. Row (a): speed of convergence; the color bars represent the numbers of iterations needed to converge to the optimum solution; Rows (b) and (c): 2D view of the error surface superimposed with convergence trajectories with different initial values of β and h; the color bars represent the value of log(SSE). The intersections of dotted lines indicate the optimum values of parameters β and h.

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