A model of gene-gene and gene-environment interactions and its implications for targeting environmental interventions by genotype

Table 3 Further constraints on model parameters

Condition	Limits on p^DZ_g	Limits on c_SD
V_e≥ 0	$p_{g}^{D Z} \leq p_{g t o p}^{D Z}$
V_ge≥ 0	$p_{g}^{D Z} \geq p_{g \min}^{D Z}$
V_g≥ 0		C_SD≤ R_SD
γ_max ≥ γ_min		If λ_MD> y_e+ 1 require: c_SD≥ c_SDmwhere $c_{S D m} = 1 - \frac{(λ_{D Z} - 1) (1 - R_{S D}) [c_{M D} + f_{g e}^{2} (λ_{D Z} - 1) R_{M D} + y_{e} f_{g e}^{2} (c_{M D} - 1)]}{[1 + f_{g e}^{2} (λ_{D Z} - 1)] [(λ_{D Z} - 1) R_{M D} - y_{e}]}$

ISSN: 1742-4682