Genetic effect in highexposure group only

1/PAF^{E}_{e}

R
_{
00
}

R
_{
ge
}

Positive

γ_{maxge} (where PAF^{E}_{ge} = PAF^{E}_{e}; PI = 1; and U_{ge} = 1γ).

γ_{minge} (where R_{ge} = 1).

 
R
_{
00
}

R
_{
0e
}
   
Multiplicative

1

R
_{
g0
}

R
_{
g0
}
R
_{
0e
}
/R
_{
00
}
 
γ_{maxge} = γ_{0} (where PAF^{E}_{ge} = PAF^{E}_{e}; R_{00} = 0; and PAF^{G}_{g} = 1).
 
 
R
_{
00
}

R
_{
0e
}
   
Additive

0

R
_{
g0
}

R
_{
g0
}
+R
_{
0e
}
R
_{
00
}

Zero

γ_{0} (where R_{00} = 0).
 
 
R
_{
00
}

R
_{
0e
}
   
Reverse multiplicative

r_{t}/(1r_{t})

R
_{
g0
}

(1R
_{
g0
}
) (1
R
_{
0e
}
)/
(1R
_{
00
}
)

Negative
 
γ_{neg} = γ_{minge} (where PAF^{E}_{ge} = 0 and R_{ge} = 1)

 
R
_{
00
}

R
_{
0e
}
   
Genetic effect in lowexposure group only

ε/(1ε)PAF^{E}_{e}

R
_{
g0
}

R
_{
0e
}
  
γ_{neg} (where PAF^{E}_{ge} = 0 and PI = 0).

 
R
_{
00
}

R
_{
0e
}
   