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Table 4 Limits on the gene-environment interaction factor (fge) and the proportion of the population in the high-genotypic risk group (γ).
| Gene-environment interaction model | Interaction factor fge | Risk distribution | Utility Uge | Fraction of population at high genotypic risk | ||
|---|---|---|---|---|---|---|
| Maximum γmax | Minimum γmin | |||||
| Genetic effect in high-exposure group only | 1/PAFEe | R 00 | R ge | Positive | γmaxge (where PAFEge = PAFEe; PI = 1; and Uge = 1-γ). | γminge (where Rge = 1). |
| R 00 | R 0e | |||||
| Multiplicative | 1 | R g0 | R g0 R 0e /R 00 | γmaxge = γ0 (where PAFEge = PAFEe; R00 = 0; and PAFGg = 1). | ||
| R 00 | R 0e | |||||
| Additive | 0 | R g0 | R g0 +R 0e -R 00 | Zero | γ0 (where R00 = 0). | |
| R 00 | R 0e | |||||
| Reverse multiplicative | -rt/(1-rt) | R g0 | (1-R g0 ) (1- R 0e )/ (1-R 00 ) | Negative | γneg = γminge (where PAFEge = 0 and Rge = 1) | |
| R 00 | R 0e | |||||
| Genetic effect in low-exposure group only | -ε/(1-ε)PAFEe | R g0 | R 0e | γneg (where PAFEge = 0 and PI = 0). | ||
| R 00 | R 0e | |||||
