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Table 2 The results of parameter optimization for scenario B (estimation of molecular diffusion coefficient in a FRAP experiment).

From: Identification of biomolecule mass transport and binding rate parameters in living cells by inverse modeling

Estimate D f
Initial guesses Optimized values   
D f (μm2 s-1) K a * MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaacqWGlbWsdaqhaaWcbaGaemyyaegabaGaeiOkaOcaaaaa@301F@ (s-1) K d (s-1) D f (μm2 s-1) K a * MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaacqWGlbWsdaqhaaWcbaGaemyyaegabaGaeiOkaOcaaaaa@301F@ (s-1) K d (s-1) RMSE R 2
3 30 0.1108 29.9975 (29.8032) 30 0.1108 0.00 (0.01) 1.0000 (0.9984)
5 30 0.1108 29.9968 (29.7362) 30 0.1108 0.00 (0.01) 1.0000 (0.9984)
10 30 0.1108 29.9968 (29.7978) 30 0.1108 0.00 (0.01) 1.0000 (0.9984)
15 30 0.1108 29.9959 (29.7483) 30 0.1108 0.00 (0.01) 1.0000 (0.9984)
20 30 0.1108 29.9972 (29.7490) 30 0.1108 0.00 (0.01) 1.0000 (0.9984)
45 30 0.1108 29.9974 (29.7376) 30 0.1108 0.00 (0.01) 1.0000 (0.9984)
1000 30 0.1108 29.9973 (29.7507) 30 0.1108 0.00 (0.01) 1.0000 (0.9984)
500 30 0.1108 29.9969 (29.7910) 30 0.1108 0.00 (0.01) 1.0000 (0.9984)
  1. The values in parentheses were obtained using corrupted data.