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Table 4 The results of parameter optimization for scenario B (estimation of dissociation rate coefficient in a FRAP experiment).

From: Identification of biomolecule mass transport and binding rate parameters in living cells by inverse modeling

Estimate K d
Initial guesses Optimized values   
D f (μm2 s-1) K a * MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaacqWGlbWsdaqhaaWcbaGaemyyaegabaGaeiOkaOcaaaaa@301F@ (s-1) K d (s-1) D f (μm2 s-1) K a * MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaacqWGlbWsdaqhaaWcbaGaemyyaegabaGaeiOkaOcaaaaa@301F@ (s-1) K d (s-1) RMSE R 2
30 30 0.0008 30 30 0.1108 (0.1107) 0.0000 (0.0102) 1.000 (0.998)
30 300 0.8000 30 30 0.1108 (0.1107) 0.0000 (0.0102) 1.000 (0.998)
30 30 0.0001 30 30 0.1108 (0.1107) 0.0000 (0.0102) 1.000 (0.998)
30 30 1.0000 30 30 0.1108 (0.1107) 0.0000 (0.0102) 1.000 (0.998)
30 30 0.0500 30 30 0.1108 (0.1107) 0.0000 (0.0102) 1.000 (0.998)
30 30 0.0010 30 30 0.1108 (0.1107) 0.0000 (0.0102) 1.000 (0.998)
30 30 1 × 10-5 30 30 0.1108 (0.1108) 0.0000 (0.0102) 1.000 (0.998)
30 30 1 × 10-6 30 30 0.1108 (0.1107) 0.0000 (0.0102) 1.000 (0.998)
  1. The values in parentheses were obtained using corrupted data.