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Table 5 The results of parameter optimization for scenario C (estimation of two parameters in a FRAP experiment: K a * MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaacqWGlbWsdaqhaaWcbaGaemyyaegabaGaeiOkaOcaaaaa@301F@ - K d ).

From: Identification of biomolecule mass transport and binding rate parameters in living cells by inverse modeling

Estimate K a and K d
Initial guesses Optimized values   
D f (μm2 s-1) K a * MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaacqWGlbWsdaqhaaWcbaGaemyyaegabaGaeiOkaOcaaaaa@301F@ (s-1) K d (s-1) D f (μm2s-1) K a * MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaacqWGlbWsdaqhaaWcbaGaemyyaegabaGaeiOkaOcaaaaa@301F@ (s-1) K d (s-1) RMSE R 2
30 90 0.005 30 30.0246 (32.7366) 0.1108 (0.1122) 0.00 (0.01) 1.000 (0.99)
30 20 0.01 30 29.9762 (28.8955) 0.1108 (0.1101) 0.00 (0.01) 1.000 (0.99)
30 250 0.01 30 30.0729 (33.7009) 0.1108 (0.1128) 0.00 (0.01) 1.000 (0.99)
30 435 0.0005 30 30.1108 (34.2443) 0.1108 (0.1131) 0.00 (0.01) 1.000 (0.99)
30 10 0.01 30 29.9576 (31.8386) 0.1108 (0.1118) 0.00 (0.01) 1.000 (0.99)
30 100 1 30 30.0027 (36.0428) 0.1108 (0.1141) 0.00 (0.01) 1.000 (0.99)
30 100 2*106 30 30.0209 (33.8034) 0.1108 (0.1129) 0.00 (0.01) 1.000 (0.99)
30 1000 0.5 30 30.0082 (32.7609) 0.1108 (0.1122) 0.00 (0.01) 1.000 (0.99)
  1. The values in parentheses were obtained using corrupted data.