Skip to main content

Table 6 The results of parameter optimization for scenario C (estimation of two parameters in a FRAP experiment: D f - K d ).

From: Identification of biomolecule mass transport and binding rate parameters in living cells by inverse modeling

Estimate D f and K d
Initial guesses Optimized values   
D f (μm2 s-1) K a * MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaacqWGlbWsdaqhaaWcbaGaemyyaegabaGaeiOkaOcaaaaa@301F@ (s-1) K d (s-1) D f (μm2 s-1) K a * MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaacqWGlbWsdaqhaaWcbaGaemyyaegabaGaeiOkaOcaaaaa@301F@ (s-1) K d (s-1) RMSE R 2
8 30 0.008 30.0111 (27.528) 30 0.1108 (0.1122) 0.000 (0.0101) 1.000 (0.998)
48 30 0.08 29.9972 (29.935) 30 0.1108 (0.1108) 0.000 (0.0101) 1.000 (0.998)
8 30 1 29.9989 (28.204) 30 0.1108 (0.1118) 0.000 (0.0101) 1.000 (0.998)
80 30 1 30.0100 (28.294) 30 0.1108 (0.1117) 0.000 (0.0101) 1.000 (0.998)
150 30 0.01 30.0156 (36.477) 30 0.1108 (0.1077) 0.000 (0.0104) 1.000 (0.998)
0.150 30 0.1 30.0005 (27.822) 30 0.1108 (0.1120) 0.000 (0.0101) 1.000 (0.998)
15 30 0.001 30.0090 (24.555) 30 0.1108 (0.1143) 0.000 (0.0102) 1.000 (0.998)
150 30 0.001 30.0142 (188.225) 30 0.1108 (0.0946) 0.000 (0.0133) 1.000 (0.998)
  1. The values in parentheses were obtained using corrupted data.