From: In silico experimentation with a model of hepatic mitochondrial folate metabolism
Cytosolic | Mitochondrial | ||||||
---|---|---|---|---|---|---|---|
Concentrations (μM) | Velocities (μM/h) | Concentrations (μM) | Velocities (μM/h) | ||||
THF | 3.74 | MTD | -113 | THF | 20.8 | MTD | 2106 |
5,10-CH = THF | 0.26 | MTCH | -113 | 5,10-CH = THF | 1.55 | MTCH | 2106 |
5,10-CH2-THF | 0.46 | FTS | 546 | 5,10-CH2-THF | 1.7 | FTS | -1639 |
10f-THF | 3.23 | FTD | 69.4 | 10f-THF | 16.0 | FTD | 467 |
5mTHF | 5.55 | SHMT | 9.2 | Â | Â | SHMT | 84.3 |
DHF | 0.035 | NE | 46.1 | Â | Â | NE | 279 |
Aicar | 0.95 | AICART | 182 | Â | Â | GDC | 1560 |
 |  | DHFR | 120 |  |  | SDH | 122 |
 |  | TS | 120 |  |  | DMGD | 60.7 |
Ser | 551 | MTHFR | 47.7 | Ser | 1963 | Â | Â |
Gly | 830 | PGT | 182 | Gly | 1858 | Â | Â |
HCOOH | 14.5 | MS | 47.7 | HCOOH | 59.9 | Â | Â |
Met | 51.9 | BHMT | 60.7 | Â | Â | Â | Â |
SAM | 63.6 | CBS | 99.7 | Â | Â | Â | Â |
SAH | 13.1 | DNMT | 147 | Â | Â | Â | Â |
Hcy | 1.10 | GNMT | 61.4 | Â | Â | Â | Â |
 |  | MAT-I | 132 |  |  |  |  |
 |  | MAT-III | 76.1 |  |  |  |  |