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Figure 1 | Theoretical Biology and Medical Modelling

Figure 1

From: Bringing metabolic networks to life: convenience rate law and thermodynamic constraints

Figure 1

System parameters for convenience kinetics. The homoserine kinase reaction (HK, dotted box) transforms homoserine and ATP into O-phospho-homoserine and ADP (solid arrows). Threonine inhibits the enzyme (dotted arrow). Each node and each arrow carries one of the system parameters: each metabolite is characterised by an energy constant kG, the reaction by a velocity constant kV, and each arrow by a kM or kI value. The system parameters are thermodynamically independent and can assume arbitrary positive values. The turnover rates k ± c a t MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaacqWGRbWAdaqhaaWcbaGaeyySaelabaacbaGae83yamMae8xyaeMae8hDaqhaaaaa@342E@ for forward and backward direction can be computed from the system parameters.

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