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Table 1 Tumor cell survival fraction as a function of changes in the states of transformation, differentiation, and the initial tumor survival fraction.

From: A stochastic model of oncogene expression and the relevance of this model to cancer therapy

fs(Pre)

Ω(Pre)-> Ω(Post)

ω(Pre)->ω(Post)

fs(Post)

1.0

3->0

1->1

.50

1.0

3->1

2->2

.77

1.0

3->1

2->1

.50

1.0

3->2

3->2

.77

1.0

3->2

3->3

.92

.85

3->2

3->3

.74

.85

3->2

3->2

.57

  1. The term fs(Pre) is the survival fraction of a tumor cell's population prior to the application of a targeted therapy; Ω(Pre)-> Ω(Post) represents the change in transformed states resulting from oncogene inhibition ; ω(Pre)->ω(Post) represents the change in differentiation states resulting from oncogene inhibition. The term fs(Post) is the survival fraction or reduced proliferation of a tumor cell population that results from oncogene inhibition and is calculated from equation (7).