From: A multiscale mathematical model of cancer, and its use in analyzing irradiation therapies
Boolean model | |
---|---|
Node | Boolean updating function |
APC t |
APC t+1= 0 if mutated |
βcat t | βcat t+1= ¬APC t |
cmyc t | cmyc t+1= RAS t∧ βcat t∧ ¬SMAD t |
p27t | p27t+1= SMAD t∨ ¬cmyc t |
p21t | p21t+1= p53t |
Bax t | Bax t+1= p53t |
SMAD t |
SMAD t+1= 0 if mutated |
RAS t |
RAS t+1= 1 if mutated |
p53t |
p53t+1= 0 if mutated |
CycCDK t | CycCDK t+1= ¬p21t∧ ¬p27t |
Rb t | Rb t+1= ¬CycCDK t |