Simulation V – edge-growth with chest-wall trophism and differential tropism. At the start of Simulation V, cells within each PPF are designated as belonging to an anterior (green) or posterior (yellow) polyclone. The simulation series shown here are color-coded by polyclone (top row) or cell cycle phase (bottom row). Model cells display behavior as in Simulation IV (Fig. 14); however, tropism of anterior polyclone cells favors the anterior body wall, and tropism of posterior polyclone cells favors the posterior body wall (differential tropism). The diaphragm morphology, with enlarged CDH defect and more normal ipsilateral anterior diaphragm, is a better match to experimental findings (see Fig. 5).