Genetically-induced mouse CDH. (A) Diaphragm from a normal (control) newborn mouse. (B) Left-sided diaphragmatic defect (arrow) in a COUP-TFII null mutant. Spinal cord is identified for orientation (SC). (Reproduced with editorial permission from ). This type of experimental defect is described as "dorsolateral" although it appears to differ in location from the classic posterolateral defect of human CDH (see text and Fig. 2).