Figure 17
From: Computer simulation analysis of normal and abnormal development of the mammalian diaphragm
Genetically-induced mouse CDH. (A) Diaphragm from a normal (control) newborn mouse. (B) Left-sided diaphragmatic defect (arrow) in a COUP-TFII null mutant. Spinal cord is identified for orientation (SC). (Reproduced with editorial permission from [24]). This type of experimental defect is described as "dorsolateral" although it appears to differ in location from the classic posterolateral defect of human CDH (see text and Fig. 2).