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Table 1 Cellular calculus within Nudge++â„¢

From: Computer simulation analysis of normal and abnormal development of the mammalian diaphragm

Internal States

+

External Cues

→

Cell Actions

age

 

boundaries

 

growth

cell-cycle phase

 

local position

 

division

phase-age

 

global position

 

movement

generation

   

death

clone

    

lineage

    
  1. Individual model cells evaluate internal states and environmental cues and carry out specific actions based on this evaluation. Additional states, cues and actions other than those listed can be added to each column. A cohort of model cells forms a tissue or organ. Simulations represent the pooled behavior of these cell cohorts over simulated tissue time. Details of these procedures have been presented elsewhere[16].