Computer simulation analysis of normal and abnormal development of the mammalian diaphragm

Table 2 Sequential achievement of modeling goals

	Simulation I	Simulation II	Simulation III	Simulation IV	Simulation V
	Homogeneous Growth	Edge Growth	Edge Growth with Chest Wall Trophism	Edge Growth with Chest Wall Trophism and Tropism	Edge Growth with Chest Wall Trophism and Differential Tropism
Development from PPF alone	+	+	+	+	+
Non-muscular central tendon	+	+	+	+	+
Central before peripheral differentiation		+	+	+	+
Anterior extension along body wall			+/-	+	+
Curvilinear morphology of hemidiaphragm				+	+
Normal anterior diaphragm ipsilateral to CDH				+/-	+
Posterior PPF persists as large CDH					+

The success of individual simulations in reproducing major observed morphological components of the developing normal and CDH diaphragm are tabulated; (+), component present; (+/-), component partially present.

ISSN: 1742-4682