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Figure 1 | Theoretical Biology and Medical Modelling

Figure 1

From: Dynamically simulating the interaction of midazolam and the CYP3A4 inhibitor itraconazole using individual coupled whole-body physiologically-based pharmacokinetic (WB-PBPK) models

Figure 1

a) Schematic representation of the CYP3A4-, CYP3A5- and UGT-catalyzed metabolic pathway for MDZ. The percentages of the administered MDZ dose which are excreted in the urine within 24 hours [11,12] are given below the compounds. Abbreviations: MDZ, midazolam; 1OH-MDZ, 1-hydroxymidazolam; 4OH-MDZ, 4-hydroxymidazolam; 1,4-di-OH-MDZ, 1,4-dihydroxymidazolam; 1OH-MDZ-Glu, 1-hydroxymidazolam glucuronide; 1,4-di-OH-MDZ-Glu, 1,4-dihydroxymidazolam glucuronide; 4-OH-MDZ-Glu, 4-hydroxymidazolam glucuronide; UGT, uridine diphosphate-glucuronosyl-transferase. b) Schematic representation of the simplified metabolic pathway for MDZ used in the coupled model approach.

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Theoretical Biology and Medical Modelling

ISSN: 1742-4682