Figure 10From: Dynamically simulating the interaction of midazolam and the CYP3A4 inhibitor itraconazole using individual coupled whole-body physiologically-based pharmacokinetic (WB-PBPK) modelsSchematic representation of the inhibition of the CYP3A4-catalyzed MDZ hydroxylation by ITZ and its major metabolite OH-ITZ (a) and the simplified model used in this study (b).Back to article page