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Figure 2 | Theoretical Biology and Medical Modelling

Figure 2

From: Dynamically simulating the interaction of midazolam and the CYP3A4 inhibitor itraconazole using individual coupled whole-body physiologically-based pharmacokinetic (WB-PBPK) models

Figure 2

Simulated plasma concentration time curve (line) of a) MDZ following a 15 minute intravenous infusion of 0.1 mg/kg MDZ and b) 1OH-MDZ following a 15 minute intravenous infusion of 0.15 mg/kg 1OH-MDZ as compared to mean experimental data. Experimental data was taken from Mandema et al. [15].

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Theoretical Biology and Medical Modelling

ISSN: 1742-4682