Figure 4From: Dynamically simulating the interaction of midazolam and the CYP3A4 inhibitor itraconazole using individual coupled whole-body physiologically-based pharmacokinetic (WB-PBPK) modelsPredicted plasma concentration time curves (lines) of MDZ, 1OH-MDZ and 1OH-MDZ-Glu following an intravenous bolus administration of 1 mg MDZ as compared to experimental data from a typical individual (symbols). Experimental data was taken from Kharasch et al. [16].Back to article page