Simulated (line) ITZ plasma concentration time curve following 15 days of 200 mg once per day ITZ administration in the fed state. Mean experimental data (symbols: squares) for the first day was taken from Barone et al.  and experimental data (mean ± SD, symbols: circles) was taken from Hardin et al. . The inset graph presents the estimated fraction of remaining CYP3A activity over time as a result of ITZ and OH-ITZ inhibition.