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Figure 7 | Theoretical Biology and Medical Modelling

Figure 7

From: Dynamically simulating the interaction of midazolam and the CYP3A4 inhibitor itraconazole using individual coupled whole-body physiologically-based pharmacokinetic (WB-PBPK) models

Figure 7

Simulated (line) ITZ plasma concentration time curve following 15 days of 200 mg once per day ITZ administration in the fed state. Mean experimental data (symbols: squares) for the first day was taken from Barone et al. [17] and experimental data (mean ± SD, symbols: circles) was taken from Hardin et al. [18]. The inset graph presents the estimated fraction of remaining CYP3A activity over time as a result of ITZ and OH-ITZ inhibition.

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