Figure 8From: Dynamically simulating the interaction of midazolam and the CYP3A4 inhibitor itraconazole using individual coupled whole-body physiologically-based pharmacokinetic (WB-PBPK) modelsComparison of observed and predicted tissue/plasma partition coefficients for the various organs (left: log-log plot, right: enlarged linear plot of the interval [0,3.5]). Small symbols indicate individual data reported by Björkmann et al. [22], large symbols denote the mean value for each organ. The solid line represents the identity, the dotted lines mark the region 3-fold-off the identity.Back to article page