Figure 9From: Dynamically simulating the interaction of midazolam and the CYP3A4 inhibitor itraconazole using individual coupled whole-body physiologically-based pharmacokinetic (WB-PBPK) modelsFraction of remaining CYP3A activity in pooled human liver microsomes in relation to the unbound inhibitor concentrations of ITZ and OH-ITZ. Data points, as taken from Isoherranen et al. [13], were fit to a logistic, 3 parameter model and the equations were used to generate a percentage of CYP3A activity remaining, constrained between 0 and 1.Back to article page