Table 1 Mean, minimum and maximum parameter values from the optimization of the coupled WB-PBPK model using the Heizmann et al. [11] data (n = 6) and the Kharasch et al. [16] mean data.

1OH_k₁ [L·umol^-1·min^-1]

5.6E^-2

4.1E^-2

7.4E^-2

2.7E^-2

1OH_k_-1 [min^-1]

8.1E^-6

4.3E^-21

4.8E^-5

1.1E^-11

1OH_k₂ [min^-1]

0.12

0.086

0.24

0.14

CL(1OH) [L·min^-1]

75.1

56.7

97.4

1OH_K_m [umol·L^-1]

2.2

1.4

3.9

5.3

1OH_V_max [umol·min^-1·g_tissue^-1]

3.4E^-4

2.2E^-4

6.6E^-4

4.0E^-4

Glu_k₁ [L·umol^-1·min^-1]

1.1

Glu_k_-1 [min^-1]

2.6E^-9

Glu_k₂ [min^-1]

0.11

Glu_K_m [umol·L^-1]

0.10

Glu_V_max [umol·min^-1·g_tissue^-1]

7.7E^-5

CL(Glu) [L·min^-1]

14.5