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Table 2 Physicochemical properties of MDZ, 1OH-MDZ, 1OH-MDZ-Glu and ITZ.

From: Dynamically simulating the interaction of midazolam and the CYP3A4 inhibitor itraconazole using individual coupled whole-body physiologically-based pharmacokinetic (WB-PBPK) models

Parameter MDZ 1OH-MDZ 1OH-MDZ-Glu ITZ
Lipophilicity (Log MA)a 2.9 2.6 1.4 3.84
funbound 0.024 0.03 0.03 0.016b
Molecular weight (g/mol) 325.8 341.8 517.9 705.6
Effective molecular weight (g/mol) 286.8 (1Cl, 1F) 302.8 (1Cl, 1F) 478.9 (1Cl, 1F) 661.6 (2Cl)
  1. a MA = Membrane Affinity
  2. b Experimental value taken from [42].