Figure 1
Total cell counts A and flow cytometric data B for untreated cells. Discrete symbols designate averages of three independent realizations of the experiment while curves are the predictions of our model. In panel A the total number of cells is shown in blue while the number of nonproliferating cells is shown in red. This prediction agrees well with the measurements in Figure 2 B. In panel B the fraction of cells in each phase is shown. In this and in the subsequent figures individual symbols mark experimental measurements while the curves are the corresponding simulations. Total cell counts C and flow cytometric data D for cells treated with 1 μM lapatinib. These graphs are representative of all drug treatment cases.