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Table 1 Numerical values of the parameters that are fixed throughout all scenarios

From: A mathematical model separates quantitatively the cytostatic and cytotoxic effects of a HER2 tyrosine kinase inhibitor

parameter

numerical value

remarks

a G 1 MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaacqWGHbqydaWgaaWcbaGaem4raC0aaSbaaWqaaiabigdaXaqabaaaleqaaaaa@3062@

7 h

G1/S-boundary in absence of drugs

a S

11 h

S/G2-boundary in absence of drugs

a m

15 h

minimal age for division

a M

30 h

maximal cell age

σ

2

standard deviation of intermitotic times

c

0.22

nonproliferation constant

M 0

6·105 cells

crowding threshold for nonproliferation

μ(a)

{1, 0.25, 0.6}

see Figure 6 B