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Table 2 Cytostatic and cytotoxic effects as functions of drug dose. See equations (11) and (12) for explanations

From: A mathematical model separates quantitatively the cytostatic and cytotoxic effects of a HER2 tyrosine kinase inhibitor

drug concentration (d, μM)

0.1

0.5

1

2

δ G 1 MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaaiiGacqWF0oazdaWgaaWcbaGaem4raC0aaSbaaWqaaiabigdaXaqabaaaleqaaaaa@30C3@ (d) (dimensionless)

0.3

0.6

0.77

0.92

δ G 2 MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaaiiGacqWF0oazdaWgaaWcbaGaem4raC0aaSbaaWqaaiabikdaYaqabaaaleqaaaaa@30C5@ (d) (dimensionless)

0

0

0

0.8

ε0(d) (h-1)

6·10-4

1.1·10-3

1.3·10-3

1.8·10-3

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Theoretical Biology and Medical Modelling

ISSN: 1742-4682