Figure 6
Colloidal particles. SC-35 speckles are formed by granules that behave as colloidal particles. (A) When the particles are not electrically charged (green circles with grey halo), excluding volume effects are the dominant force determining structure. (B) When particles become charged (phosphorylated, red halo around green circles), repulsive forces are stronger than excluding volume forces and the interchromatin granule clusters become destabilized.