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Table 2 Estimated patterns in distinguishing dynamic from static enzymes.

From: Distinguishing enzymes using metabolome data for the hybrid dynamic/static method

E. coli
w 1.000   0.750   0.500   0.250   0.100   0.075   0.050   0.025   0.010  
Noise - + - + - + - + - + - + - + - + - +
Fitness (-) 7.83 × 10-1 3.37 7.13 × 10-1 3.30 6.42 × 10-1 3.23 5.71 × 10-1 3.16 5.06 × 10-1 3.09 4.94 × 10-1 3.08 4.82 × 10-1 3.07 4.69 × 10-1 3.05 4.59 × 10-1 3.04
PGI S S S S S S S S S S S S S S S D D D
PFK D D D D D D D D D D D D D D D D D D
ALDO D D D D D D D D D D D D D D D D D D
TIS S S S S S S S S S S S S S S S S S S
GAPDH D D D D D D D D D D D D D D D D D D
PGK D D D D D D D D D D D D D D D D D D
PGluMu D D D D D D D D D D D D D D D D D D
ENO D D D D D D D D D D D D D D D D D D
PK D D D D D D D D D D D D D D D D D D
PGM S S S S S S S S S S S S S S S D D D
G6PDH D D D D D D D D D D D D D D D D D D
PGDH D D D D D D D D D D D D D D D D D D
Ru5P S S S S S S S S S S S S S S S S S D
R5PI S S S S S S D S D D D D D D D D D D
TKa S S S S S S S S S S S S S S S S D S
TKb S S S S S S D D D D D D D D D D D D
TA S S S S S S S S D D D D D D D S D S
S. cerevisiae                   
w 1000   0.750   0.500   0.250   0.100   0.075   0.050   0.025   0.010  
Noise - + - + - + - + - + - + - + - + - +
Fitness (-) 3.35 × 10-1 1.75 × 101 2.64 × 10-1 1.75 × 101 1.94 × 10-1 1.74 × 101 1.10 × 10-1 1.73 × 101 5.42 × 10-2 1.73 × 101 4.17 × 10-2 1.73 × 101 4.17 × 10-2 1.73 × 101 1.68 × 10-2 1.72 × 101 8.02 × 10-3 1.72 × 101
PGI D D D D D D D D D D D D D D D D D D
PFK D D D D D D D D D D D D D D D D D D
ALDO D D D D D D D D D D D D D D D D D D
TIS S S S D S D D D D D D D D D D D D D
GAPDH D D D D D D D D D D D D D D D D D D
PGK D D D D D D D D D D D D D D D D D D
PGluMu D D D D D D D D D D D D D D D D D D
ENO D S D S D S D S D S D S D S D S D S
PK D D D D D D D D D D D D D D D D D D
PGM S S S S S S S S S S S S S S S S D S
G6PDH D D D D D D D D D D D D D D D D D D
PGDH S S S S S S S S S S S S S S S S S S
Ru5P S S S S S S S D D D D D D D D D D D
R5PI S S S S S S S S S S S S S S S S D D
TKa S S S S S S S S S S S S S S S S S S
TKb S S S S S S S S D S D S D S D S D S
TA S S S S S S S S S S S S S D S D D D
  1. w is the weighting coefficient in the fitness function (Eq. (5)), and the symbols D and S denote enzymes in the dynamic and static modules, respectively. The system boundary enzymes were omitted from the table because all system boundary enzymes were represented as dynamic enzymes.