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Figure 3 | Theoretical Biology and Medical Modelling

Figure 3

From: The relationship between twitch depression and twitch fade during neuromuscular block produced by vecuronium: correlation with the release of acetylcholine

Figure 3

Upper panel: The ratios of the fourth to the first twitch (T4/T1) as a function of T1. The 11 curves were obtained in simulations assuming a constant amount of acetylcholine released by the first stimulus ([A]1) and either the same or smaller amounts released by the fourth stimulus ([A]4). The ratios of the initial concentrations of acetylcholine released by the fourth and the first stimulus are denoted by [A]4/[A]1. The continuous bold curves indicate, in descending order, [A]4/[A]1 ratios of 1.0, 0.9, 0.8, and 0.7, respectively. For the intermediate values of [A]4/[A]1 see Methods. Lower panel: The observed T4/T1-T1 data pairs during the onset of NMB and the mean values during the offset are inserted into the grid of the T4/T1 versus T1 curves presented in the upper panel. The observed data are those presented in Figure 2.

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