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Table 1 Significant coefficients generated by fitting the SERD equation to the survival curves shown in Figures 1, 2 and 3.

From: A general framework for quantifying the effects of DNA repair inhibitors on radiation sensitivity as a function of dose

Cell line

Parameter

Value (± standard error)

p-value*

CHO-K1 (Fig 1a)

α

0.142 (± 0.021)

<0.0001

 

β

0.043 (± 0.005)

<0.0001

 

δz

-0.133 (± 0.023)

<0.0001

 

δα

0.112 (± 0.015)

<0.0001

 

δG

34.649 (± 12.328)

0.005

 

δd C

0.037 (± 0.008)

<0.0001

V79-379A (Fig 1b)

α

0.187 (± 0.019)

<0.0001

 

β

0.016 (± 0.004)

0.0003

 

G

2.235 (± 0.666)

0.0009

 

d C

0.161 (± 0.031)

<0.0001

 

δz

-0.184 (± 0.017)

<0.0001

T98G exponential phase (Fig 2a)

α

0.208 (± 0.006)

<0.0001

 

δz

-0.101 (± 0.014)

<0.0001

 

δG

10.116 (± 10.374)

0.330

 

δG

7.81

0.020

 

δd C

0.033 (± 0.019)

0.076

 

δβ

0.013 (± 0.002)

<0.0001

T98G growth-arrested (Fig 2b)

α

0.175 (± 0.003)

<0.0001

 

δz

0.051 (± 0.007)

<0.0001

 

δα

-0.017 (± 0.005)

0.0005

U373-MG exponential phase (Fig 3a)

α

0.270 (± 0.011)

<0.0001

 

δz

0.068 (± 0.021)

0.002

 

δβ

0.028 (± 0.004)

<0.0001

U373-MG growth-arrested (Fig 3b)

α

0.126 (± 0.014)

<0.0001

 

β

0.031 (± 0.003)

<0.0001

 

δz

-0.044 (± 0.012)

0.0002

  1. * Log-likelihood ratio test (L-ratio) was applied to include or drop parameters from the final equation. p-values shown were derived from a t-test that the parameter is zero. The L-ratio and associated p-value is shown only when the tests did not agree (i.e. significance in one but not the other).