Figure 6

For data set 1: the estimated rate functions and parameters of PDE model (4) and ODE model (15) and the kinetics of the total number of live lymphocytes predicted by both models. Left: Dependence of the estimated turnover functions α(z) and β(z⁾ on the log₁₀-transformed marker intensity. The best-fit estimates a _k , k = 1, ..., 21, are indicated by circles. Stars specify the best-fit estimates for the birth and death parameters α _j , β _j , j = 0, ..., 5, of the ODE model (15). They are placed in the middle of the CFSE intervals which correspond to subsequent division numbers starting from 0. Right: The kinetics of the total number of live lymphocytes for data set 1 (circle) predicted by the PDE and ODE models (solid and dashed curves, respectively).