Table 6 Enhanced ADT Treatment
From: Can a single model explain both breast cancer and prostate cancer?
Treatment | Results | Effects |
|---|---|---|
Maximum antagonism of mAR | ↓apoptotic proteins ↑bcl-2 (BC only) ↓bcl-2 (PC only) ↑AS3 ↓Ca++ influx | ↓ RD ↓ RD ↑ RD ↓ RG ↓ RD |
Maximum antagonism of iAR | ↑apoptotic proteins ↑bcl-2 ↓AS3 ↑Ca++ influx ↓calreticulin | ↑ RD ↓ RD ↑ RG ↑ RD ↑ RD |
Maximum antagonism of ER-α | ↓bcl-2 | ↑ RD |
Maximum agonism of ER-β | ↓bcl-2 | ↑ RD |
Maximum antagonism of mER | ↓bcl-2 | ↑ RD |
Maximum antagonism of PRA | ↓bcl-2 | ↑ RD |
Maximum agonism of PRB | ↓bcl-2 | ↑ RD |
Maximum agonism of mPR | ↓bcl-2 | ↑ RD |
Maximum calcitriol | ↑kill mitochondria | ↑ RD |