Table 9 AMAI Treatment
From: Can a single model explain both breast cancer and prostate cancer?
Treatment | Results | Effects |
|---|---|---|
Maximum agonism of mAR | ↑apoptotic proteins ↓bcl-2 (BC only) ↑bcl-2 (PC only) ↓AS3 ↑Ca++ influx | ↑ RD ↑ RD ↓ RD ↑ RG ↑ RD |
Maximum agonism of iAR | ↓apoptotic proteins ↓bcl-2 ↑AS3 ↓Ca++ influx ↑calreticulin | ↓ RD ↑ RD ↓ RG ↓ RD ↓ RD |
Maximum antagonism of ER-α | ↓bcl-2 | ↑ RD |
Maximum agonism of ER-β | ↓bcl-2 | ↑ RD |
Maximum antagonism of mER | ↓bcl-2 | ↑ RD |
Maximum antagonism of PRA | ↓bcl-2 | ↑ RD |
Maximum agonism of PRB | ↓bcl-2 | ↑ RD |
Maximum agonism of mPR | ↓bcl-2 | ↑ RD |
Maximum calcitriol | ↑AS3 ↑kill mitochondria | ↓ RG ↑ RD |